Peer-reviewed publications

 

2020

Hoogendijk, E.O., Smit, A.P., van Dam, C., Schuster N.A., de Breij, S., Holwerda, T.J., Huisman, M., Dent, E., Andrew, M.K. (in press). Frailty combined with loneliness or social isolation: an elevated risk for mortality in later life. Journal of the American Geriatrics Society. DOI: 10.1111/jgs.16716 (OPEN ACCESS)

Holwerda, T.J., & Hoogendijk, E.O. (in press). Invited commentary: Adult child migration and parental cognitive decline – A new perspective on loneliness and social isolation. American Journal of Epidemiology. DOI: 10.1093/aje/kwz278 (OPEN ACCESS)

Suanet, B., Aartsen M.J., Hoogendijk, E.O., & Huisman M. (in press). The social support-health link unraveled: pathways linking social support to functional capacity in later life. Journal of Aging and Health. DOI: 10.1177/0898264319841949

Hoogendijk, E.O., Stenholm, S., Ferrucci, L., Bandinelli, S., Inzitari, M., & Cesari, M. (2020). Operationalization of a frailty index among older adults in the InCHIANTI study: Predictive ability for all-cause and cardiovascular disease mortality. Aging Clinical and Experimental Research, 32, 1025-1034. DOI: 10.1007/s40520-020-01478-3 (OPEN ACCESS)

Vallet, A., Del Campo, N., Hoogendijk, E.O., Lokossou, A., Balédent, O., Czosnyka, Z., Balardy, L., Payoux, P., Swider, P., Lorthois, S., & Schmidt, E. (2020). Biomechanical response of the CNS is associated with frailty in NPH-suspected patients. Journal of Neurology, 267, 1389-1400. DOI: 10.1007/s00415-019-09689-z

Schuster, N.A., Hoogendijk E.O., Kok, A.A.L., Twisk, J.W.R., & Heymans, M.W. (2020). Ignoring competing events in the analysis of survival data may lead to biased results: a nonmathematical illustration of competing risk analysis. Journal of Clinical Epidemiology, 122, 42-48. DOI: 10.1016/j.jclinepi.2020.03.004 (OPEN ACCESS)

Machado-Fragua, M.D., Hoogendijk, E.O., Struijk, E.A., Rodriguez-Artalejo, F., López-García, E., Beulens, J.W., & van Ballegooijen, A.J. (2020). High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam. European Journal of Nutrition, 59, 1243-1251. DOI: 10.1007/s00394-019-01984-9

Park, J., Sherman, D.G., Agogo, G., Hoogendijk E.O., & Liu, Z. (2020). Frailty modifies the intervention effect of chair yoga on pain among older adults with lower extremity osteoarthritis: Seconday analysis of a nonpharmacological intervention trial. Experimental Gerontology, 134, 110886. DOI: 10.1016/j.exger.2020.110886

Hoogendijk, E.O., Deeg, D.J.H., de Breij, S., Klokgieters, S.S., Kok, A.A.L., Stringa, N., Timmermans, E.J., van Schoor, N.M., van Zutphen, E.M., van der Horst, M., Poppelaars, J., Malhoe, P., & Huisman, M. (2020). The Longitudinal Aging Study Amsterdam: Cohort update 2019 and additional data collections. European Journal of Epidemiology, 35, 61-74. DOI: 10.1007/s10654-019-00541-2 (OPEN ACCESS)

Lin, H., Guo, Y., Ruan, Z., Kowal, P., Di, Q., Zheng, Y., Xiao, J., Hoogendijk, E.O., Dent, E., Vaughn, M.G., Howard, S.W., Cao, Z., Ma, W., Qian, Z., & Wu, F. (2020). Association of indoor and outdoor air pollution with hand-grip strength among adults in six low- and middle-income countries. Journal of Gerontology: Medical Sciences, 75, 340-347. DOI: 10.1093/gerona/glz038

Jeuring, H.W., Hoogendijk, E.O., Comijs, H.C., Deeg, D.J.H., Beekman, A.T.F., Huisman, M., & Stek, M.L. (2020). The tide has turned: Incidence of depression declined in community living young-old adults over one decade. Epidemiology and Psychiatric Sciences, 29, e16, 1-8. DOI: 10.1017/S2045796018000811 (OPEN ACCESS)

Hoogendijk, E.O., Rijnhart, J.J.M., Skoog, J., Robitaille, A., van den Hout, A., Ferrucci, L., Huisman, M., Skoog, I., Piccinin, A.M., Hofer, S.M., & Muniz Terrera, G. (2020). Gait speed as predictor of transition into cognitive impairment: Findings from three longitudinal studies on aging. Experimental Gerontology, 129, 110783. DOI: 10.1016/j.exger.2019.110783 (OPEN ACCESS)

2019

Timmermans, E.J., Hoogendijk, E.O., Broese van Groenou, M.I., Comijs, H.C., van Schoor, N.M., Thomése, F., Visser, M., Deeg, D.J.H., & Huisman, M. (2019). Trends across 20 years in multiple indicators of functioning among older adults in the Netherlands. European Journal of Public Health, 29, 1096-1102. DOI: 10.1093/eurpub/ckz065

Hoogendijk, E.O., Afilalo, J., Ensrud, K.E., Kowal, P., Onder, G., & Fried, L.P. (2019). Frailty: implications for clinical practice and public health. The Lancet, 394, 1365-1375. DOI: 10.1016/S0140-6736(19)31786-6 

Dent, E., Morley, J.E., Cruz-Jentoft, A.J., Woodhouse, L., Rodríguez-Mañas, L., Fried, L.P., Woo, J., Aprahamian, I., Sanford, A., Lundy, J., Landi, F., Beilby, J., Martin, F.C., Bauer, J.M., Ferrucci, L., Merchant, R.A., Dong, B., Arai, H., Hoogendijk, E.O., Won, C.W., Abbatecola, A., Cederholm, T., Strandberg, T., Gutiérrez Robledo, L.M., Flicker, L., Bashin, S., Aubertin-Leheudre, M., Bischoff-Ferrari, H.A., Guralnik, J.M., Muscedere, J., Pahor, M., Ruiz, J., Negm, A.M., Reginster, J.Y., Waters, D.L., & Vellas B. (2019). Physical frailty: ICFSR International clinical practice guidelines for identification and management. Journal of Nutrition, Health & Aging, 23, 771-787. DOI: 10.1007/s12603-019-1273-z

Dent, E., Hoogendijk, E.O., Visvanathan, R., & Wright, O.R.L. (2019). Malnutrition screening and assessment in hospitalised older people: A review. Journal of Nutrition, Health & Aging, 23, 431-441. DOI: 10.1007/s12603-019-1176-z

Hoogendijk, E.O., Romero, L., Sánchez-Jurado, P.M., Flores Ruano, T., Viña, J., Rodríguez-Mañas, L, & Abizanda, P. (2019). A new functional classification based on frailty and disability stratifies the risk for mortality among older adults: The FRADEA Study. Journal of the American Medical Directors Association, 20, 1105-110. DOI: 10.1016/j.jamda.2019.01.129

Generaal, E., Hoogendijk, E.O., Stam, M., Henke, C., Rutters, F., Oosterman, M., Huisman, M., Kramer, S.E., Elders, P.J.M., Timmermans, E.J., Lakerveld, J., Koomen, E., ten Have, M., de Graaf, R., Snijder, M.B., Stronks, K., Willemsen, G., Boomsma, D.I., Smit, J.H., & Penninx, B.W.J.H. (2019). Neighbourhood characteristics and prevalence and severity of depression: a pooled analysis of eight Dutch cohort studies. British Journal of Psychiatry, 215, 468-475. DOI: 10.1192/bjp.2019.100

Stenholm S., Ferrucci, L., Vahtera, J., Hoogendijk, E.O., Huisman, M., Pentti, J., Lindbohm, J.V., Bandinelli, S., Guralnik, J., & Kivimäki, M. (2019). Natural course of frailty components in people who develop frailty syndrome: Evidence from two cohort studies. Journal of Gerontology: Medical Sciences, 74, 667-674. DOI: 10.1093/gerona/gly132

Hoogendijk, E.O., van der Noordt, M., Onwuteaka-Philipsen, B.D., Deeg, D.J.H., Huisman, M., Enroth, L., & Jylhä , M. (2019). Sex differences in healthy life expectancy among nonagenarians: A multistate survival model using data from the Vitality 90+ study. Experimental Gerontology, 116, 80-85. DOI: 10.1016/j.exger.2018.12.015

Dent, E., Hoogendijk, E.O., & Wright O. (2019). New insights into the anorexia of ageing: From prevention to treatment. Current Opinion in Clinical Nutrition and Metabolic Care, 22, 44-51. DOI: 10.1097/MCO.0000000000000525

2018

Deeg, D.J.H, Comijs, H.C., Hoogendijk, E.O., van der Noordt, M., & Huisman, M. (2018). 23-year trends in life expectancy in good and poor physical and cognitive health of 65-year-olds in the Netherlands (1993-2016). American Journal of Public Health, 108, 1652-1658. DOI: 10.2105/AJPH.2018.304685

Hoogendijk, E.O., Flores Ruano, T., Martínez-Reig, M., López-Utiel, M., Lozoya-Moreno, S., Dent, E., & Abizanda, P. (2018). Socioeconomic position and malnutrition among older adults: Results from the FRADEA study. Journal of Nutrition, Health & Aging, 22, 1086-1091. DOI: 10.1007/s12603-018-1061-1

Hoogendijk, E.O., Rockwood, K., Theou, O., Armstrong, J.J., Onwuteaka-Philipsen, B.D., Deeg, D.J.H., & Huisman, M. (2018). Tracking changes in frailty throughout later life: results from a 17-year longitudinal study in the Netherlands. Age and Ageing, 47, 727-733. DOI: 10.1093/ageing/afy081

Hoogendijk, E.O., Rijnhart, J.J.M., Kowal, P., Pérez-Zepeda, M.U., Cesari, M., Abizanda, P., Flores Ruano, T., Schop-Etman, A., Huisman, M., & Dent, E. (2018). Socioeconomic inequalities in frailty among older adults in six low- and middle-income countries: Results from the WHO Study on global AGEing and adult health (SAGE). Maturitas, 115, 56-63. DOI: 10.1016/j.maturitas.2018.06.011

Kleipool, E.E.F., Hoogendijk, E.O., Trappenburg, M., Handoko, M.L., Huisman, M., Peters, M.J.L., & Muller, M. (2018). Frailty in older adults with cardiovascular disease: cause, effect or both? Aging and Disease, 9, 489-497. DOI: 10.14336/AD.2017.1125

Martínez-Reig, M., Aranda-Reneo, I., Peña-Longobardo, L.M., Oliva-Moreno, J., Barcons-Vilardell, N., Hoogendijk, E.O., & Abizanda, P. (2018). Use of health resources and healthcare costs associated with nutritional risk: The FRADEA Study. Clinical Nutrition, 37, 1299-1305. DOI: 10.1016/j.clnu.2017.05.021

Van Ballegooijen, A.J., van Putten, S.R., Visser, M., Beulens, J.W., & Hoogendijk, E.O. (2018). Vitamin K status and physical decline in older adults – The Longitudinal Aging Study Amsterdam. Maturitas, 113, 73-79. DOI: 10.1016/j.maturitas.2018.04.013

Hermsen, L.A.H., Hoogendijk, E.O., van der Wouden, J.C., Smalbrugge, M., Leone, S.S., van der Horst, H.E., & Dekker, J. (2018). Self-perceived care needs in older adults with joint pain and comorbidity. Aging Clinical and Experimental Research, 30, 449-455. DOI: 10.1007/s40520-017-0795-7

Robitaille, A., van den Hout, A., Machado, R.J.M., Bennett, D.A., Cukic, I., Deary, I.J., Hofer, S.M., Hoogendijk, E.O., Huisman, M., Johansson, B., Koval, A., van der Noordt, M., Piccinin, A.M., Rijnhart, J.J.M., Sing-Manoux, A., Skoog, J., Skoog, I., Starr, J., Vermunt, L., Clouston, S., & Muniz Terrera, G. (2018). Transitions across cognitive states and death among older adults in relation to education: a multi-state survival model using data from six longitudinal studies. Alzheimer`s & Dementia, 14, 462-472. DOI: 10.1016/j.jalz.2017.10.003

Dent, E., Hoogendijk, E.O., & Moldovan, M. (2018). A Frailty Index from routine laboratory measurements (FI-LAB) correlates with leukocyte telomere length. Geriatrics & Gerontology International, 18, 654-655. DOI: 10.1111/ggi.13257

Jeuring, H.W., Comijs, H.C., Deeg, D.J.H., Hoogendijk, E.O., Beekman, A.T.F., Stek, M.L., & Huisman, M. (2018). Secular trends in excess mortality of late-life depression. Journal of Affective Disorders, 234, 28-33. DOI: 10.1016/j.jad.2018.02.068

Hoogendijk, E.O., Heymans, M.W., Deeg, D.J.H., & Huisman, M. (2018). Socioeconomic inequalities in frailty among older adults: Results from a 10-year longitudinal study in the Netherlands. Gerontology, 64, 157-164. DOI: 10.1159/000481943

Dent, E., Wright, O., Hoogendijk, E.O., & Hubbard, R.E. (2018). Nutritional screening and dietitian consultation rates in a Geriatric Evaluation and Management Unit. Nutrition & Dietetics, 75, 11-16. DOI: 10.1111/1747-0080.12391

2017

Hoogendijk, E.O., Theou, O., Rockwood, K., Onwuteaka-Philipsen, B.D., Deeg, D.J.H., & Huisman, M. (2017). Development and validation of a frailty index in the Longitudinal Aging Study Amsterdam. Aging Clinical and Experimental Research, 29, 927-933. DOI: 10.1007/s40520-016-0689-0

Costa, N., Hoogendijk, E.O., Mounié, M., Bourrel, R., Rolland, Y., Vellas, B., Molinier, L., & Cesari, M. (2017). Additional cost because of pneumonia in nursing home residents: Results from the Incidence of Pneumonia and Related Consequences in Nursing Home Resident Study. Journal of the American Medical Directors Association, 18, 453.e7–453.e12. DOI: 10.1016/j.jamda.2017.01.021

Hoogendijk, E.O., Huisman, M., & van Ballegooijen, A.J. (2017). The role of frailty in explaining the association between the metabolic syndrome and mortality in older adults. Experimental Gerontology, 91, 5-8. DOI: 10.1016/j.exger.2017.02.007

2016

Hoogendijk, E.O. (2016). How effective is integrated care for community-dwelling frail older people? The case of the Netherlands. Age and Ageing, 45, 587-590. DOI: 10.1093/ageing/afw081

Del Campo, N., Cesari, M., Canevelli, M., Hoogendijk, E.O., Lilamand, M., Kelaiditi, E., Soto, M., Ousset, P-J., Weiner, M., Andrieu, S., Vellas, B., & the ICTUS and REAL.FR / DSA groups. (2016). Refining mild-to-moderate Alzheimer`s disease screening: A tool for clinicians. Journal of the American Medical Directors Association, 17, 913-920. DOI: 10.1016/j.jamda.2016.06.005

Hoogendijk, E.O., Deeg, D.J.H., Poppelaars, J., van der Horst, M., Broese van Groenou, M.I., Comijs, H.C.,  Pasman, H.R.W., van Schoor, N.M., Suanet, B., Thomése, F., van Tilburg, T.G., Visser, M., & Huisman, M. (2016). The Longitudinal Aging Study Amsterdam: cohort update 2016 and major findings. European Journal of Epidemiology, 31, 927-945. DOI: 10.1007/s10654-016-0192-0

Sutorius, F., Hoogendijk, E.O., Prins, B.A., & van Hout, H.P.J. (2016). Comparison of 10 single and stepped methods to identify frail older persons in primary care: diagnostic and prognostic accuracy. BMC Family Practice, 17, 102. DOI: 10.1186/s12875-016-0487-y

Zengarini, E., Hoogendijk E.O., Perez-Zepeda, M.U., Ruggiero, C., Mecocci, P., Vellas, B., & Cesari, M. (2016). Lack of energy and negative health-related outcomes in nursing home residents: Results from the INCUR study. Journal of the American Medical Directors Association, 17, 525-529. DOI: 10.1016/j.jamda.2016.02.005

Dent, E., Kowal, P., & Hoogendijk, E.O. (2016). Frailty measurement in research and clinical practice: A review. European Journal of Internal Medicine, 31, 3-10. DOI: 10.1016/j.ejim.2016.03.007

Cesari, M., Costa, N., Hoogendijk, E.O., Vellas B., Canevelli, M., & Perez-Zepeda, M.U. (2016). How the frailty index may support the allocation of healthcare resources – An example from the INCUR study. Journal of the American Medical Directors Association, 17, 448-450. DOI: 10.1016/j.jamda.2016.02.007

Hoogendijk, E.O., Del Campo, N., Rolland, Y., Demougeot, L., Gerard, S., Vellas, B., & Cesari, M. (2016). Adverse effects of pneumonia on physical functioning in nursing home residents: Results from the INCUR study. Archives of Gerontology and Geriatrics, 65, 116-121. DOI: 10.1016/j.archger.2016.03.011

Twisk, J.W.R., Hoogendijk, E.O., Zwijsen, S.A., & de Boer, M.R. (2016). Different methods to analyse stepped wedge trial designs revealed different aspects of intervention effects. Journal of Clinical Epidemiology, 72, 75-83. DOI: 10.1016/j.jclinepi.2015.11.004

Hoogendijk, E.O., van der Horst, H.E., van de Ven, P.M., Twisk, J.W.R., Deeg, D.J.H., Frijters, D.H.M., van Leeuwen, K.M., van Campen, J.P.C.M., Nijpels, G., Jansen, A.P.D., & van Hout, H.P.J. (2016). Effectiveness of a geriatric care model for frail older adults in primary care: Results from a stepped wedge cluster randomized trial. European Jounal of Internal Medicine, 28, 43-51. DOI: 10.1016/j.ejim.2015.10.023

Fougere, B., Kelaiditi, E., Hoogendijk, E.O., Demougeot, L., Duboué, M., Vellas, B., & Cesari, M. (2016). Frailty Index and quality of life in nursing home residents: Results from INCUR study. Journal of Gerontology: Medical Sciences, 71, 420-424. DOI: 10.1093/gerona/glv098

Dent, E., Hoogendijk, E.O., Cardona-Morrell, M., & Hillman, K. (2016). Frailty in emergency departments (correspondence). The Lancet, 387, 434. DOI: 10.1016/S0140-6736(16)00177-X

Del Campo, N., Payoux, P., Djilali, A., Delrieu, J., Hoogendijk, E.O., Rolland, Y., Cesari, M., Weiner, M., Andrieu, S., Vellas, B., & the MAPT/DSA study group (2016). Relationship of regional brain beta-amyloid to gait speed. Neurology, 86, 36-43.  DOI: 10.1212/WNL.0000000000002235

Hoogendijk, E.O., Suanet, B., Dent, E., Deeg, D.J.H, & Aartsen, M.J. (2016). Adverse effects of frailty on social functioning in older adults: Results from the Longitudinal Aging Study Amsterdam. Maturitas, 83, 45-50. DOI: 10.1016/j.maturitas.2015.09.002

2015

Van Leeuwen, K.M., Bosmans, J.E., Jansen, A.P.D, Hoogendijk, E.O., Muntinga, M.E., van Hout, H.P.J., Nijpels, G., van der Horst, H.E., & van Tulder M.W. (2015). Cost-effectiveness of a chronic care model for frail older adults in primary care: economic evaluation alongside a stepped wedge cluster randomized trial. Journal of the American Geriatrics Society, 63, 2494-2504. DOI: 10.1111/jgs.13834

Marzetti, E., Calvani, R., Landi, F., Hoogendijk, E.O., Fougere, B., Vellas, B., Pahor, M., Bernabei, R., Cesari, M., & the SPRINTT consortium (2015). Innovative medicines initiative: The SPRINTT project. Journal of Frailty & Aging, 4, 207-208Journal website.

Hoogendijk, E.O., Abellan van Kan, G., Guyonnet, S., Vellas, B., & Cesari, M. (2015). Components of the frailty phenotype in relation to the frailty index: Results from the Toulouse Frailty Platform. Journal of the American Medical Directors Association, 16, 855-859. DOI: 10.1016/j.jamda.2015.04.007

Zengarini, E., Ruggiero, C., Perez-Zepeda, M.U., Hoogendijk, E.O., Vellas, B., Mecocci, P., & Cesari M. (2015). Fatigue: Relevance and implications in the aging population. Experimental Gerontology, 70, 78-83. DOI: 10.1016/j.exger.2015.07.011

Hoogendijk, E.O., Abellan van Kan, G., Guyonnet, S., Vellas, B., & Cesari, M. (2015). Operationalization of a frailty index using routine data from the Toulouse Frailty Clinic. Geriatrics & Gerontology International, 15, 519-520. DOI: 10.1111/ggi.12403

Van Leeuwen, K.M., Bosmans, J.E., Jansen, A.P.D., Hoogendijk, E.O. , Van Tulder, M.W., Van der Horst, H.E., & Ostelo, R.W. (2015). Comparing measurement properties of the EQ-5D, ICECAP-O and ASCOT in frail older adults. Value in Health, 18, 35-43. DOI: 10.1016/j.jval.2014.09.006

Dent, E., & Hoogendijk, E.O. (2015). Psychosocial resources: moderators or mediators of frailty outcomes? Journal of the American Medical Directors Association, 16, 258-259. DOI: 10.1016/j.jamda.2014.11.014

2014

Hoogendijk, E.O., van Hout, H.P.J., van der Horst, H.E., Frijters, D.H.M., Dent, E., Deeg, D.J.H.,& Huisman, M. (2014). Do psychosocial resources modify the effects of frailty on functional decline and mortality? Journal of Psychosomatic research, 77, 547-551. DOI: 10.1016/j.jpsychores.2014.09.017

Dent, E, & Hoogendijk, E.O. (2014). Psychosocial factors modify the association of frailty with adverse outcomes: A prospective study of hospitalised older people. BMC Geriatrics, 14, 108. DOI: 10.1186/1471-2318-14-108

Hoogendijk, E.O. (2014). How useful are multidomain frailty measures in research and clinical practice? Journal of Frailty & Aging, 3, 193-194. Journal website.

Hoogendijk, E.O., van Hout, H.P.J., Heymans, M.W., van der Horst, H.E., Frijters, D.H.M., Broese van Groenou, M.I., Deeg, D.J.H., & Huisman, M. (2014). Explaining the association between educational level and frailty in older adults: Results from a 13-year longitudinal study in the Netherlands. Annals of Epidemiology, 24, 538-544. DOI: 10.1016/j.annepidem.2014.05.002

Hoogendijk, E.O., Muntinga, M.E., van Leeuwen, K.M., van der Horst, H.E., Deeg, D.J.H., Frijters, D.H.M., Hermsen, L.A.H., Jansen, A.P.D., Nijpels, G., & van Hout, H.P.J. (2014). Self-perceived met and unmet care needs of frail older adults in primary care. Archives of Gerontology and Geriatrics, 58, 37-42. DOI: 10.1016/j.archger.2013.09.001

2013

Hoogendijk, E.O., van der Horst, H.E., Deeg, D.J.H., Frijters, D.H.M., Prins, B.A.H., Jansen, A.P.D., Nijpels, G., & van Hout, H.P.J. (2013). The identification of frail older adults in primary care: comparing the accuracy of five simple instruments. Age and Ageing, 42, 262-265. DOI: 10.1093/ageing/afs163

Broese van Groenou, M.I., Hoogendijk, E.O., & van Tilburg, T.G. (2013). Continued and new personal relationships in later life: Differential effects of health. Journal of Aging and Health, 25, 274-295. DOI: 10.1177/0898264312468033

2012

Hoogendijk, E.O., & van Hout, H.P.J. (2012). Investigating measurement properties of the Groningen Frailty Indicator: A more systematic approach is needed. Journal of the American Medical Directors Association, 13, 757-758. DOI: 10.1016/j.jamda.2012.06.008

Muntinga, M.E., Hoogendijk, E.O., van Leeuwen, K.M., van Hout, H.P.J., Twisk, J.W.R., van der Horst, H.E., Nijpels G.N., & Jansen, A.P.D. (2012). Implementing the chronic care model for frail older adults in the Netherlands: Study protocol of ACT (frail older Adults: Care in Transition). BMC Geriatrics, 12, 19. DOI: 10.1186/1471-2318-12-19

2008

Hoogendijk, E., Broese van Groenou, M., van Tilburg, T., & Deeg, D. (2008). Educational differences in functional limitations: Comparisons of 55-65-year-olds in the Netherlands in 1992 and 2002. International Journal of Public Health53, 281-289. DOI: 10.1007/s00038-008-8079-9